June 25, 2024

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Study backs Wegovy use to cut heart attacks and strokes

2 min read

Novo Nordisk A/S unveiled details from a closely watched study that support use of Wegovy, its blockbuster weight-loss drug, to cut heart attacks and strokes in obesity patients with a history of cardiovascular disease.

People taking the highest dose of Wegovy saw a drop in blood sugar levels and inflammation — two harbingers of heart disease — that help explain the 20% reduction in cardiovascular events that Novo reported in August. While none of the patients had diabetes, two-thirds started the study with blood sugar levels in the prediabetic range, which is associated with a higher risk of heart disease and death. Patients also saw significant reductions in blood pressure.

Three-quarters of patients had suffered heart attacks before the study began and a quarter had heart failure. In this highly vulnerable population, the results help cement the argument for using Novo’s drug as a heart treatment alongside statins and blood pressure therapies. Patients on Wegovy also lost weight in the trial.

The results, presented on Saturday at the American Heart Association’s annual conference in Philadelphia, are “game-changing,” Eugene Yang, the chair of the American College of Cardiology’s prevention section, said in an interview. The room at the city’s Convention Center erupted into several rounds of applause when the data were presented.

Heart disease is the number one killer in the US and accounts for about a third of deaths globally. While obesity is known to raise the risk for such ailments, Novo’s trial was designed to show whether Wegovy could ward off future heart attacks and strokes in people with established cardiovascular disease.

Novo said it will seek expanded US approval for reducing risk of major adverse cardiovascular events in adults with a body mass index, or BMI, of 27 or higher and established cardiovascular disease.

Read More: All About the New Obesity Drugs Causing a Big Stir

“Increasingly, physicians…

Madison Muller, Naomi Kresge, Bloomberg

2023-11-11 10:35:12

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